Friday, September 07, 2012

Graphene nanocomposite for biomedical applications: fabrication, antimicrobial and cytotoxic investigations

Catherine M Santos, Joey Mangadlao, Farid Ahmed, Alex Leon, Rigoberto C Advincula and Debora F Rodrigues



Materials possessing excellent bacterial toxicity, while presenting low cytotoxicity to human cells, are strong candidates for biomaterials applications. In this study, we present the fabrication of a nanocomposite containing poly( N -vinylcarbazole) (PVK) and graphene (G) in solutions and thin films. Highly dispersed PVK–G (97-3 w/w%) solutions in various organic and aqueous solvents were prepared by solution mixing and sonication methods. The thermal properties and morphology of the new composite were analyzed using thermal gravimetry analysis (TGA) and atomic force microscopy (AFM), respectively. PVK–G films were immobilized onto indium tin oxide (ITO) substrates via electrodeposition. AFM was used to characterize the resulting topography of the nanocomposite thin films, while cyclic voltammetry and UV–vis were used to monitor their successful electrodeposition. The antimicrobial properties of the electrodeposited PVK–G films and solution-based PVK–G were investigated aga...



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