Wednesday, April 03, 2013

Modifying mesoporous silica nano-particle to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy

Shiqi Peng



, 2013, Accepted Manuscript

DOI: 10.1039/C3NR00227F, Communication

Chen-Jie Fang, Wenjing Wang, Xiaozhu Wang, Yu-Xi Chen, Wei Feng, Chun-Hua Yan, Ming Zhao, Shiqi Peng

Mesoporous silica nano-particle having amino and thiol groups (MSNSN) was prepared and covalently modified with methotrexate and 6-mercaptopurine to form 6-MP-MSNSN-MTX. In the presence of DTT 6-MP-MSNSN-MTX gradually releases 6-MP....

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