New magnetic hydroxyapatite-based nanomaterials as bone-specific systems for controlled drug delivery have been synthesized. The synthesized hydroxyapatite, HA, decorated with magnetite nanoparticles by a deposition method (HA/Fe 3 O 4 ) and the nanocomposite system obtained using magnetic multi-walled carbon nanotubes (HA/MWCNT/Fe 3 O 4 ) as a filler for HA have been characterized by chemical and morphological analyses, and their biological behavior was investigated. The systems have also been doped with clodronate in order to combine the effect of bone biomineralization induced by hydroxyapatite-based composites with the decrease of osteoclast formation induced by the drug. An analysis of the preosteoclastic RAW264.7 cell proliferation by MTT assay confirmed the high biocompatibility of the three systems. TRAP staining of RAW 264.7 conditioned with sRAKL to induce osteoclastogenesis, cultured in the presence of the systems doped and undoped w...
Alessandro Pistone, Daniela Iannazzo, Silvia Panseri, Monica Montesi, Anna Tampieri and Signorino Galvagno
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Alessandro Pistone, Daniela Iannazzo, Silvia Panseri, Monica Montesi, Anna Tampieri and Signorino Galvagno
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