Nanoscale , 2014, Advance Article
DOI: 10.1039/C4NR01584C, Paper
DOI: 10.1039/C4NR01584C, Paper
Troels B. Thomsen, Leon Li, Kenneth A. Howard
This paper presents a new mechanism for chitosan-based siRNA nanocarrier interaction and transport across mucus of the gastrointestinal tract. This mechanism suggests disassembly of the nanocarriers and concomitant diffusion of siRNA through the mucus barrier. This is the first example of mucin-triggered decomplexation and transport that provide design guidelines for RNAi-based nanocarrier therapy targeted at mucosal sites.
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This paper presents a new mechanism for chitosan-based siRNA nanocarrier interaction and transport across mucus of the gastrointestinal tract. This mechanism suggests disassembly of the nanocarriers and concomitant diffusion of siRNA through the mucus barrier. This is the first example of mucin-triggered decomplexation and transport that provide design guidelines for RNAi-based nanocarrier therapy targeted at mucosal sites.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
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