Monday, January 12, 2015

Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway




Nanoscale , 2015, Advance Article

DOI: 10.1039/C4NR06300G, Paper

Nannan Zhang, Shichang Liu, Ning Wang, Senyi Deng, Linjiang Song, Qinjie Wu, Lei Liu, Weijun Su, Yuquan Wei, Yongmei Xie, Changyang Gong

For developing aqueous formulation and improving anti-tumor activity of JK184, we prepared JK184 encapsulated MPEG-PCL micelles which showed a stronger inhibition of Gli expression in Hh signaling in pancreatic carcinoma.

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