Monday, January 19, 2015

Biodegradation of carbon nanohorns in macrophage cells




Nanoscale , 2015, Advance Article

DOI: 10.1039/C4NR06175F, Feature Article

Minfang Zhang, Mei Yang, Cyrill Bussy, Sumio Iijima, Kostas Kostarelos, Masako Yudasaka

Biodegradation of carbon nanohorns by MPO catalytic oxidation and by mouse and human monocyte-derived macrophages is presented. MPO catalytic oxidation and macrophages degrade approximately 60 wt% and 30 wt% of CNHs, respectively. Uptake of CNHs by macrophage cells induces the release of reactive oxygen species that results in CNH degradation.

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