Protein denaturation at a single-molecule level: the effect of nonpolar environments and its implications on the unfolding mechanism by proteases

Nanoscale , 2015, Advance Article

DOI: 10.1039/C4NR07140A, Paper

Bo Cheng, Shaogui Wu, Shixin Liu, Piere Rodriguez-Aliaga, Jin Yu, Shuxun Cui

When pulled into a nonpolar solvent by AFM, the single molecule of a polyprotein will be denatured into an unstructured polypeptide spontaneously.

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