Friday, March 06, 2015

Quantitatively probing propensity for structural transitions in engineered virus nanoparticles by single-molecule mechanical analysis




Nanoscale , 2015, Advance Article

DOI: 10.1039/C4NR07046A, Paper

Milagros Castellanos, Pablo J. P. Carrillo, Mauricio G. Mateu

In a virus particle, the free energy barrier of an inactivating structural transition is linearly related to mechanical stiffness. Elasticity measurements may be applied for probing conformational dynamics of virus-based nanoparticles.

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