Thursday, March 19, 2015

Versatile method for AFM-tip functionalization with biomolecules: fishing a ligand by means of an in situ click reaction




Nanoscale , 2015, Advance Article

DOI: 10.1039/C5NR01495F, Paper

Rakesh Kumar, Shivaprakash N. Ramakrishna, Vikrant V. Naik, Zonglin Chu, Michael E. Drew, Nicholas D. Spencer, Yoko Yamakoshi

A method for AFM-tip functionalization is described using click chemistry between pre-immobilized tripod-acetylene on the tip and azide-connected biomolecules. It has been successfully applied to chemical force spectroscopy.

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