Employing integrated nano- and microfluidic circuits for detecting and characterizing biological compounds through resistive pulse sensing technology is a vibrant area of research at the interface of biotechnology and nanotechnology. Resistive pulse sensing platforms can be customized to study virtually any particle of choice which can be threaded through a fluidic channel and enable label-free single-particle interrogation with the primary read-out signal being an electric current fingerprint. The ability to perform label-free molecular screening with single-molecule and even single binding site resolution makes resistive pulse sensing technology a powerful tool for analyzing the smallest units of biological systems and how they interact with each other on a molecular level. This task is at the core of experimental systems biology and in particular ‘omics research which in combination with next-generation DNA-sequencing and next-generation drug discovery and design forms the fou...
S Harrer, S C Kim, C Schieber, S Kannam, N Gunn, S Moore, D Scott, R Bathgate, S Skafidas and J M Wagner
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S Harrer, S C Kim, C Schieber, S Kannam, N Gunn, S Moore, D Scott, R Bathgate, S Skafidas and J M Wagner
Click for full article
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