Real-Time Investigation of Human Topoisomerase I Reaction Kinetics using an Optical Sensor: A Fast Method for Drug Screening and Determination of Active Enzyme Concentrations

Nanoscale, 2015, Accepted Manuscript
DOI: 10.1039/C5NR01474C, Paper

Emil L Kristoffersen, Line A Jorgensen, Oskar Franch, Michael Etzerodt, Rikke Frohlich, Lotte Bjegbaek, Magnus Stougaard, Yi-Ping Ho, Birgitta R. Knudsen
Human DNA topoisomerase I (hTopI) is a nuclear enzyme that catalyzes relaxation of super helical tension that arises in the genome during essential DNA metabolic processes. This is accomplished through...
The content of this RSS Feed (c) The Royal Society of Chemistry

Click for full article