Monday, July 27, 2015

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

Nanoscale, 2015, Advance Article
DOI: 10.1039/C5NR03178H, Paper
Edward D. H. Mansfield, Katy Sillence, Patrick Hole, Adrian C. Williams, Vitaliy V. Khutoryanskiy
The permeation of thiolated silica nanoparticles through porcine gastric mucosa can be significantly enhanced by their functionalization with either 5 kDa poly(2-ethyl-2-oxazoline) or poly(ethylene glycol). The enhancement of nanoparticle permeability through mucus gel is due to the "stealth" properties of these polymers.
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