In situ optical sequencing and structure analysis of a trinucleotide repeat genome region by localization microscopy after specific COMBO-FISH nano-probing

Nanoscale, 2015, Accepted Manuscript
DOI: 10.1039/C5NR04141D, Paper

Michael Stuhlmueller, Jutta Schwarz-Finsterle, Evelyn Fey, Johannes Thomas Lux, Margund Bach, Christoph Cremer, Katrin Hinderhofer, Michael Hausmann, Georg Hildenbrand
Trinucleotide expansions (like CGG) of chromatin in the genome of cell nuclei cause neurological disorders such as for example the Fragile-X syndrome. By now mechanics is not clearly understood how...
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