Rough surface Au@Ag core–shell nanoparticles to fabricating high sensitivity SERS immunochromatographic sensors

Immunochromatographic sensors (ICSs) are inexpensive, simple, portable, and robust, thus making ICSs commonplace in clinical diagnoses, food testing, and environmental monitoring. However, commonly used gold nanoparticles (AuNPs) ICSs have low sensitivity. Therefore, we developed highly sensitive surface enhanced Raman scattering (SERS) ICSs. To enhance the sensitivity of SERS ICSs, rough surface core–shell Au@Ag nanoparticles (RSAu@AgNPs) were prepared by coating silver on the surface of gold nanoflowers (AuNFs). Then these nanoparticles were used as SERS substrate in the SERS ICSs, after which the SERS ICSs were implemented to detect haemoglobin and heavy metal cadmium ion (Cd 2+ ). The limit of detection (LOD) of the SERS ICSs for detecting haemoglobin was 8 ng/mL, and the linear range of the SERS ICSs was from 31.3 to 2000 ng/mL. The LOD of the SERS ICSs for detecting Cd 2+ was 0.05 ng/mL and the linear analysis range was from 0.05 to 25 ng/mL. The cross reactivity of the SERS ICSs was studied and results showed that the SERS ICSs exhibited highly specific for detection of haemoglobin and Cd 2+ , respectively. The SERS ICSs were then used to detect haemoglobin (spiked in serum and in stool) and Cd 2+ (spiked in tap water, river water, and soil leaching water), and the results showed high recovery. These characteristics indicated that SERS ICSs were ideal tools for clinical diagnosis and environmental pollution monitoring.
Qiangqiang Fu
Click for full article

Near IR fluorescent conjugated poly(ethylene glycol)bisphosphonate nanoparticles for in vivo bone targeting in a young mouse model

Bisphosphonate (BP) compounds are widely used in the treatment of bone disorders. This group of drugs with a high affinity to Ca +2 ions is rapidly attracted to bone mineral, especially in areas of high resorption. We have engineered unique biodegradable BP nanoparticles (NPs) by dispersion co-polymerization of the monomers methacrylate-PEG-BP) and (3-Aminopropyl)mathacrylamide) with the crosslinker monomer tetra ethylene glycol diacrylate. These NPs possess a dual functionality: (1) covalent attachment of a dye (e.g. near IR dye) or a drug to the nanoparticles through the primary amine groups on the surface of the NPs; (2) chelation to the bone mineral hydroxyapatite through the BP on the surface of the NPs. This study describes the uptake of the unique near IR fluorescent Cy 7-conjugated BP NPs in bone of a young mouse model. Blood half-life studies revealed a relatively long half-life (approximately 5 h) due to a high concentration of PEG in the BP NPs as well as a relatively long whole body clearance (approximately 2 weeks). Body distribution studies showed a specific uptake of the BP NPs in bone. These unique engineered BP NPs are planned to be utilized in future work for diagnostic and drug delivery systems that are targeted to bone disorders.
S. Rudnick-Glick
Click for full article

Local Characterization of Ultrathin ZnO Layers on Ag(111) by Scanning Tunneling Microscopy and Atomic Force Microscopy

The Journal of Physical Chemistry C

DOI: 10.1021/jp509013p

Akitoshi Shiotari, Bo Hong Liu, Simon Jaekel, Leonhard Grill, Shamil Shaikhutdinov, Hans-Joachim Freund, Martin Wolf and Takashi Kumagai

Click for full article

Raman Scattering Study of Cu3SnS4 Colloidal Nanocrystals

The Journal of Physical Chemistry C

DOI: 10.1021/jp509035f

Volodymyr M. Dzhagan, Alexander P. Litvinchuk, Marta Kruszynska, Joanna Kolny-Olesiak, Mykhailo Ya. Valakh and Dietrich R. T. Zahn

Click for full article

Evidence of Unfolded Protein Translocation through a Protein Nanopore

ACS Nano

DOI: 10.1021/nn5042398

Manuela Pastoriza-Gallego, Marie-France Breton, Françoise Discala, Loïc Auvray, Jean-Michel Betton and Juan Pelta

Click for full article

Light-Induced Cytosolic Activation of Reduction-Sensitive Camptothecin-Loaded Polymeric Micelles for Spatiotemporally Controlled in Vivo Chemotherapy

ACS Nano

DOI: 10.1021/nn504836s

Hung-Chi Yen, Horacio Cabral, Peng Mi, Kazuko Toh, Yu Matsumoto, Xueying Liu, Hiroshi Koori, Ahram Kim, Kozo Miyazaki, Yutaka Miura, Nobuhiro Nishiyama and Kazunori Kataoka

Click for full article

Spontaneous Graphitization of Ultrathin Cubic Structures: A Computational Study

Nano Letters

DOI: 10.1021/nl503673q

Pavel B. Sorokin, Alexander G. Kvashnin, Zhen Zhu and David Tománek

Click for full article

Enhancement of Initial Growth of ZnO Films on Layer-Structured Bi2Te3 by Atomic Layer Deposition

Chemistry of Materials

DOI: 10.1021/cm502940v

Kwang-Chon Kim, Cheol Jin Cho, Joohwi Lee, Hyun Jae Kim, Doo Seok Jeong, Seung-Hyub Baek, Jin-Sang Kim and Seong Keun Kim

Click for full article

Structural Evolution of GdBaCo2O5+δ (δ = 7/18) at Elevated Temperatures

Chemistry of Materials

DOI: 10.1021/cm503132e

Nobuo Ishizawa, Toru Asaka, Tatsunari Kudo, Koichiro Fukuda, Akira Yasuhara, Nobuyuki Abe and Taka-hisa Arima

Click for full article

Reversible Oxidation of Graphene Through Ultraviolet/Ozone Treatment and Its Nonthermal Reduction through Ultraviolet Irradiation

The Journal of Physical Chemistry C

DOI: 10.1021/jp508026g

Yana Mulyana, Mutsunori Uenuma, Yasuaki Ishikawa and Yukiharu Uraoka

Click for full article

Fabrication of Honeycomb Films Based on Aptamer and Binding Behavior Studies with Fluorophore-Labeled Complementary Base Sequences

The Journal of Physical Chemistry C

DOI: 10.1021/jp507798j

Dawei Fan, Xiulong Xia, Hongmin Ma, Yanfang Zhao, Guobao Li, Yan. Li, Picheng Gao, Bin Du and Qin Wei

Click for full article

Increasing the Photocatalytic Activity of Anatase TiO2 through B, C, and N Doping

The Journal of Physical Chemistry C

DOI: 10.1021/jp508882m

Christopher L. Muhich, Jay Y. Westcott, Thomas Fuerst, Alan W. Weimer and Charles B. Musgrave

Click for full article

Photoluminescence of Graphene Oxide Infiltrated into Mesoporous Silicon

The Journal of Physical Chemistry C

DOI: 10.1021/jp506539n

Ilaria Rea, Lucia Sansone, Monica Terracciano, Luca De Stefano, Principia Dardano, Michele Giordano, Anna Borriello and Maurizio Casalino

Click for full article

Dynamics of the Photogenerated Hole at the Rutile TiO2(110)/Water Interface: A Nonadiabatic Simulation Study

The Journal of Physical Chemistry C

DOI: 10.1021/jp508557w

Georgios A. Tritsaris, Dmitry Vinichenko, Grigory Kolesov, Cynthia M. Friend and Efthimios Kaxiras

Click for full article

Electropolymerization of Aniline onto Anodic WO3 Film: An Approach to Extend Polyaniline Electroactivity Beyond pH 7

The Journal of Physical Chemistry C

DOI: 10.1021/jp509268t

Zejun Chen, Huiling Lv, Xufei Zhu, Dongdong Li, Shaoyu Zhang, Xiaoyuan Chen and Ye Song

Click for full article

Coherent and Diffusive Time Scales for Exciton Dissociation in Bulk Heterojunction Photovoltaic Cells

The Journal of Physical Chemistry C

DOI: 10.1021/jp508561z

K. Birgitta Whaley, Aleksey A. Kocherzhenko and Abraham Nitzan

Click for full article

Rutile Surface Reactivity Provides Insight into the Structure-Directing Role of Peroxide in TiO2 Polymorph Control

The Journal of Physical Chemistry C

DOI: 10.1021/jp507292v

Anqi Song, Dapeng Jing and Melissa A. Hines

Click for full article

Ambient Air Processing Causes Light Soaking Effects in Inverted Organic Solar Cells Employing Conjugated Polyelectrolyte Electron Transfer Layer

The Journal of Physical Chemistry C

DOI: 10.1021/jp507742j

Chang-Yong Nam

Click for full article

Self-Assembled ErSb Nanostructures with Optical Applications in Infrared and Terahertz

Nano Letters

DOI: 10.1021/nl402436g

Hong Lu, Daniel G. Ouellette, Sascha Preu, Justin D. Watts, Benjamin Zaks, Peter G. Burke, Mark S. Sherwin and Arthur C. Gossard

Click for full article