Tuesday, June 23, 2015

Dendritic Nanoconjugates for Intracellular Delivery of Neutral Oligonucleotides

Nanoscale, 2015, Accepted Manuscript
DOI: 10.1039/C5NR01665G, Communication
Xin Ming, Lin Wu, Kyle Carver, Ahu Yuan, Yuanzeng Min
Dendrimer-based gene delivery has been constrained by intrinsic toxicity and suboptimal nanostructure. Conjugation of neutral morpholino oligonucleotides (ONs) with PAMAM dendrimers resulted in neutral, uniform, and ultra-small (~10nm) nanoconjugates. The...
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