Gold decorated NaYF4:Yb,Er/NaYF4/silica (core/shell/shell) upconversion nanoparticles for photothermal destruction of BE(2)-C neuroblastoma cells

Gold decorated NaYF4:Yb,Er/NaYF4/silica (core/shell/shell) upconversion nanoparticles for photothermal destruction of BE(2)-C neuroblastoma cells: "

Abstract

Gold decorated NaYF₄:Yb,Er/NaYF₄/silica (core/shell/shell) upconversion (UC) nanoparticles (~70–80 nm) were synthesized using tetraethyl orthosilicate and
chloroauric acid in a one-step reverse microemulsion method. Gold nanoparticles (~6 nm) were deposited on the surface of silica
shell of these core/shell/shell nanoparticles. The total upconversion emission intensity (green, red, and blue) of the core/shell/shell
nanoparticles decreased by ~31% after Au was deposited on the surface of silica shell. The upconverted green light was coupled
with the surface plasmon of Au leading to rapid heat conversion. These UC/silica/Au nanoparticles were very efficient to destroy
BE(2)-C cancer cells and showed strong potential in photothermal therapy.

• Content Type Journal Article
• DOI 10.1007/s11051-010-0080-6
• Authors
  
  • Li Peng Qian, Department of Materials Science and Engineering, National University of Singapore, Kent Ridge, Singapore, 117540 Republic of Singapore
  • Li Han Zhou, Department of Biochemistry, National University of Singapore, Kent Ridge, Singapore, 119260 Republic of Singapore
  • Heng-Phon Too, Department of Biochemistry, National University of Singapore, Kent Ridge, Singapore, 119260 Republic of Singapore
  • Gan-Moog Chow, Department of Materials Science and Engineering, National University of Singapore, Kent Ridge, Singapore, 117540 Republic of Singapore

• Journal Journal of Nanoparticle Research
• Online ISSN 1572-896X
• Print ISSN 1388-0764

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