A zeta potential value determines the aggregate’s size of penta-substituted [60]fullerene derivatives in aqueous suspension whereas positive charge is required for toxicity against bacterial cells

Background: The cause–effect relationships between physicochemical properties of amphiphilic [60]fullerene derivatives and their toxicity against bacterial cells have not yet been clarified. In this study, we report how the differences in the chemical structure of organic addends in 10 originally synthesized penta-substituted [60]fullerene derivatives modulate their zeta potential and aggregate’s size in salt-free and salt-added aqueous suspensions as well as how these physicochemical characteristics affect the bioenergetics of freshwater Escherichia coli and marine Photobacterium phosphoreum bacteria. Dynamic light scattering, laser Doppler micro-electrophoresis, agarose gel electrophoresis, atomic force microscopy, and bioluminescence inhibition assay were used to characterize the fullerene aggregation behavior in aqueous solution and their interaction with the bacterial cell surface, following zeta potential changes and toxic effects. Results: Dynamic light scattering results indicated the formation of self-assembled [60]fullerene aggregates in aqueous suspensions. The measurement of the zeta potential of the particles revealed that they have different surface charges. The relationship between these physicochemical characteristics was presented as an exponential regression that correctly described the dependence of the aggregate’s size of penta-substituted [60]fullerene derivatives in salt-free aqueous suspension from zeta potential value. The prevalence of DLVO-related effects was shown in salt-added aqueous suspension that decreased zeta potential values and affected the aggregation of [60]fullerene derivatives expressed differently for individual compounds. A bioluminescence inhibition assay demonstrated that the toxic effect of [60]fullerene derivatives against E. coli cells was strictly determined by their positive zeta potential charge value being weakened against P. phosphoreum cells in an aquatic system of high salinity. Atomic force microscopy data suggested that the activity of positively charged [60]fullerene derivatives against bacterial cells required their direct interaction. The following zeta potential inversion on the bacterial cells surface was observed as an early stage of toxicity mechanism that violates the membrane-associated energetic functions. Conclusions: The novel data about interrelations between physicochemical parameters and toxic properties of amphiphilic [60]fullerene derivatives make possible predicting their behavior in aquatic environment and their activity against bacterial cells.
Dmitry Deryabin
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Magnetic separation-based blood purification: a promising new approach for the removal of disease-causing compounds?

Recent studies report promising results regarding extracorporeal magnetic separation-based blood purification for the rapid and selective removal of disease-causing compounds from whole blood. High molecular weight compounds, bacteria and cells can be eliminated from blood within minutes, hence offering novel treatment strategies for the management of intoxications and blood stream infections. However, risks associated with incomplete particle separation and the biological consequences of particles entering circulation remain largely unclear. This article discusses the promising future of magnetic separation-based purification while keeping important safety considerations in mind.
I Herrmann
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Self-Defensive Layer-by-Layer Films with Bacteria-Triggered Antibiotic Release

ACS Nano

DOI: 10.1021/nn500674g

Iryna Zhuk, Freneil Jariwala, Athula B. Attygalle, Yong Wu, Matthew R. Libera and Svetlana A. Sukhishvili

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Direct Photocatalytic Conversion of Aldehydes to Esters Using Supported Gold Nanoparticles under Visible Light Irradiation at Room Temperature

The Journal of Physical Chemistry C

DOI: 10.1021/jp505552v

Yulin Zhang, Qi Xiao, Yongsheng Bao, Yajing Zhang, Steven Bottle, Sarina Sarina, Bao Zhaorigetu and Huaiyong Zhu

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Mechano-Electrochemistry and Fuel-Forming Mechano-Electrocatalysis on Spring Electrodes

The Journal of Physical Chemistry C

DOI: 10.1021/jp506279q

Drazenka Svedruzic and Brian A. Gregg

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Single- versus Multi-Proton-Coupled Rydberg-State Electron Transfer in Amine Clusters

The Journal of Physical Chemistry C

DOI: 10.1021/jp504041n

Xiaohua Chen and Yuxiang Bu

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Molecular Dynamics Simulation of Inverse-Phosphocholine Lipids

The Journal of Physical Chemistry C

DOI: 10.1021/jp505633y

Aniket Magarkar, Tomasz Róg and Alex Bunker

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Diffusion and Trapping of Single Particles in Pores with Combined Pressure and Dynamic Voltage

The Journal of Physical Chemistry C

DOI: 10.1021/jp505823r

Matthew Schiel and Zuzanna S. Siwy

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High-Performance All-Solid-State Supercapacitor Based on the Assembly of Graphene and Manganese(II) Phosphate Nanosheets

The Journal of Physical Chemistry C

DOI: 10.1021/jp504741u

Chao Yang, Lei Dong, Zhongxin Chen and Hongbin Lu

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Synthesis of Copper Hydroxide Branched Nanocages and Their Transformation to Copper Oxide

The Journal of Physical Chemistry C

DOI: 10.1021/jp503612k

Alec P. LaGrow, Lutfan Sinatra, Ahmed Elshewy, Kuo-Wei Huang, Khabiboulakh Katsiev, Ahmad R. Kirmani, Aram Amassian, Dalaver H. Anjum and Osman M. Bakr

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Variational Reconstruction of Exciton Multipath Deexcitation Lifetime Spectra in Coupled PbS Colloidal Quantum Dots

The Journal of Physical Chemistry C

DOI: 10.1021/jp506194y

Jing Wang and Andreas Mandelis

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Lithium-Ion Trapping from Local Structural Distortions in Sodium Super Ionic Conductor (NASICON) Electrolytes

Chemistry of Materials

DOI: 10.1021/cm5013872

Brian E. Francisco, Conrad R. Stoldt and Jean-Claude M’Peko

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Integrated Biodetection in a Nanofluidic Device

ACS Nano

DOI: 10.1021/nn502678t

Liza Rassaei, Klaus Mathwig, Shuo Kang, Hendrik A. Heering and Serge G. Lemay

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Functionalized Surface-Confined Pores: Guest Binding Directed by Lateral Noncovalent Interactions at the Solid–Liquid Interface

ACS Nano

DOI: 10.1021/nn503815q

Kazukuni Tahara, Keisuke Katayama, Matthew Oliver Blunt, Kohei Iritani, Steven De Feyter and Yoshito Tobe

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Large-Area Monolayer Hexagonal Boron Nitride on Pt Foil

ACS Nano

DOI: 10.1021/nn503140y

Ji-Hoon Park, Jin Cheol Park, Seok Joon Yun, Hyun Kim, Dinh Hoa Luong, Soo Min Kim, Soo Ho Choi, Woochul Yang, Jing Kong, Ki Kang Kim and Young Hee Lee

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ACS Nano

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Anisha Gopalakrishnan, Manohar Chirumamilla, Francesco De Angelis, Andrea Toma, Remo Proietti Zaccaria and Roman Krahne

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Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces

ACS Nano

DOI: 10.1021/nn5038652

Zijian Zhou, Zhenghuan Zhao, Hui Zhang, Zhenyu Wang, Xiaoyuan Chen, Ruifang Wang, Zhong Chen and Jinhao Gao

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Gold Nanowired: A Linear (Au25)n Polymer from Au25 Molecular Clusters

ACS Nano

DOI: 10.1021/nn5031143

Marco De Nardi, Sabrina Antonello, De-en Jiang, Fangfang Pan, Kari Rissanen, Marco Ruzzi, Alfonso Venzo, Alfonso Zoleo and Flavio Maran

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Two-Dimensional Lattice of Out-of-Plane Dinuclear Iron Centers Exhibiting Kondo Resonance

ACS Nano

DOI: 10.1021/nn502765g

Tao Lin, Guowen Kuang, Weihua Wang and Nian Lin

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