Plasmonic Surface Lattice Resonances at the Strong Coupling Regime

Nano Letters

DOI: 10.1021/nl4035219

A. I. Väkeväinen, R. J. Moerland, H. T. Rekola, A.-P. Eskelinen, J.-P. Martikainen, D.-H. Kim and P. Törmä

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Plasmonic Surface Lattice Resonances at the Strong Coupling Regime

Nano Letters

DOI: 10.1021/nl4035219

A. I. Väkeväinen, R. J. Moerland, H. T. Rekola, A.-P. Eskelinen, J.-P. Martikainen, D.-H. Kim and P. Törmä

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Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation

Background: Cardiac toxicity is the foremost reason for drug discontinuation from development to clinical evaluation and post market surveillance [Fung 35:293-317, 2001; Piccini 158:317-326 2009]. The Food and Drug Administration (FDA) has rejected many potential pharmaceutical agents due to QT prolongation effects. Since drug development and FDA approval takes an enormous amount of time, money and effort with high failure rates, there is an increased focus on rescuing drugs that cause QT prolongation. If these otherwise safe and potent drugs were formulated in a unique way so as to mitigate the QT prolongation associated with them, these potent drugs may get FDA approval for clinical use. Rescuing these compounds not only benefit the patients who need them but also require much less time and money thus leading to faster clinical translation. In this study, we chose curcumin as our drug of choice since it has been shown to posses anti-tumor properties against various cancers with limited toxicity. The major limitations with this pharmacologically active drug are (a) its ability to prolong QT by inhibiting the hERG channel and (b) its low bioavailability. In our previous studies, we found that lipids have protective actions against hERG channel inhibition and therefore QT prolongation. Results: Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K+ channel at concentrations higher than the therapeutic concentrations of curcumin. Comparing the percent inhibition, the hybrid nanocurcumin limited inhibition to 24.8% at a high curcumin equivalent concentration of 18 muM. Liposomal curcumin could only decrease this inhibition upto 30% only at lower curcumin concentration of 6 muM but not at 18 muM concentration. Conclusions: Here we show a curcumin encapsulated lipopolymeric hybrid nanoparticle formulation which could protect against QT prolongation and also render increased bioavailability and stability thereby overcoming the limitations associated with curcumin.

Amalendu Ranjan

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Influence of Cationic Precursors on CdS Quantum-Dot-Sensitized Solar Cell Prepared by Successive Ionic Layer Adsorption and Reaction

The Journal of Physical Chemistry C

DOI: 10.1021/jp410615b

Ru Zhou, Qifeng Zhang, Jianjun Tian, Daniel Myers, Min Yin and Guozhong Cao

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Metal–Organic Framework Thin Films Composed of Free-Standing Acicular Nanorods Exhibiting Reversible Electrochromism

Chemistry of Materials

DOI: 10.1021/cm403726v

Chung-Wei Kung, Timothy Chiaan Wang, Joseph E. Mondloch, David Fairen-Jimenez, Daniel M. Gardner, Wojciech Bury, Jordan Matthew Klingsporn, Jonathan C. Barnes, Richard Van Duyne, J. Fraser Stoddart, Michael R. Wasielewski, Omar K. Farha and Joseph T. Hupp

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Plasmonic Surface Lattice Resonances at the Strong Coupling Regime

Nano Letters

DOI: 10.1021/nl4035219

A. I. Väkeväinen, R. J. Moerland, H. T. Rekola, A.-P. Eskelinen, J.-P. Martikainen, D.-H. Kim and P. Törmä

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Phase Diagram of trans–cis Isomers for Photoactive and Mesogenic 4-Hexyl-4′-propoxyazobenzene

The Journal of Physical Chemistry C

DOI: 10.1021/jp407628c

Joanna Jaworska, Stanislaw Bartkiewicz and Zbigniew Galewski

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Electrochemical Na Extraction/Insertion of Na3V2O2x(PO4)2F3–2x

Chemistry of Materials

DOI: 10.1021/cm403679b

Paula Serras, Verónica Palomares, Javier Alonso, Neeraj Sharma, Juan Miguel López del Amo, Pierre Kubiak, María Luisa Fdez-Gubieda and Teófilo Rojo

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High-Modulus, High-Conductivity Nanostructured Polymer Electrolyte Membranes via Polymerization-Induced Phase Separation

Nano Letters

DOI: 10.1021/nl4034818

Morgan W. Schulze, Lucas D. McIntosh, Marc A. Hillmyer and Timothy P. Lodge

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A Nanomechanical Fredkin Gate

Nano Letters

DOI: 10.1021/nl403268b

Josef-Stefan Wenzler, Tyler Dunn, Tommaso Toffoli and Pritiraj Mohanty

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Acoustic Surface Plasmon on Cu(111) as an Excitation in the Mid-Infrared Range

The Journal of Physical Chemistry C

DOI: 10.1021/jp407447p

Jan Pischel, Emanuel Welsch, Olaf Skibbe and Annemarie Pucci

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Doping Behavior of Zr4+ Ions in Zr4+-Doped TiO2 Nanoparticles

The Journal of Physical Chemistry C

DOI: 10.1021/jp407662d

Jingsheng Wang, Yanlong Yu, Sha Li, Limei Guo, Enjun Wang and Yaan Cao

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Evidence for the Formation of Nitrogen-Rich Platinum and Palladium Nitride Nanoparticles

Chemistry of Materials

DOI: 10.1021/cm403224m

Gabriel M. Veith, Andrew R. Lupini, Loïc Baggetto, James F. Browning, Jong K. Keum, Alberto Villa, Laura Prati, Alexander B. Papandrew, Gabriel A. Goenaga, David R. Mullins, Steven E. Bullock and Nancy J. Dudney

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Many-Body Effects in Valleytronics: Direct Measurement of Valley Lifetimes in Single-Layer MoS2

Nano Letters

DOI: 10.1021/nl403742j

Cong Mai, Andrew Barrette, Yifei Yu, Yuriy G. Semenov, Ki Wook Kim, Linyou Cao and Kenan Gundogdu

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Quick-Response Magnetic Nanospheres for Rapid, Efficient Capture and Sensitive Detection of Circulating Tumor Cells

ACS Nano

DOI: 10.1021/nn405744f

Cong-Ying Wen, Ling-Ling Wu, Zhi-Ling Zhang, Yu-Lin Liu, Shao-Zhong Wei, Jiao Hu, Man Tang, En-Ze Sun, Yi-Ping Gong, Jing Yu and Dai-Wen Pang

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Modes of Interaction of Simazine with the Surface of Amorphous Silica in Water. Part II: Adsorption at Temperatures Higher than Ambient

The Journal of Physical Chemistry C

DOI: 10.1021/jp4107487

Serena Esposito, Filomena Sannino, Marco Armandi, Barbara Bonelli and Edoardo Garrone

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Postcombustion CO2 Capture in Functionalized Porous Coordination Networks

The Journal of Physical Chemistry C

DOI: 10.1021/jp409361j

Ravichandar Babarao, Yuqi Jiang and Nikhil V. Medhekar

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Photochemical Charge Separation in Poly(3-hexylthiophene) (P3HT) Films Observed with Surface Photovoltage Spectroscopy

The Journal of Physical Chemistry C

DOI: 10.1021/jp409262v

Frank E. Osterloh, Michael A. Holmes, Lilian Chang, Adam J. Moulé and Jing Zhao

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