Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin

Background: Conspicuous facial pores are therapeutic targets for cosmeceuticals. Here we examine the effect of topical fullerene on conspicuous facial pores using a new image analyser called the VISIA(R) system. Ten healthy Japanese females participated in this study, and they received applications of 1% fullerene lotion to the face twice a day for 8 weeks.FindingsFullerene lotion significantly decreased conspicuous pores by 17.6% (p < 0.05, Wilcoxon signed-rank test) after an 8-week treatment. A self-administered questionnaire indicated that this reduction achieved cosmetically appreciable effects. In addition, to investigate the mechanism of effect of fullerene, we examined its effect on UVB-induced prostaglandin E2 (PGE2) production in reconstructed human epidermis (RhE). The results showed that irradiation of RhE with 1000 mJ/cm2 increased PGE2 production by 62.3% (p < 0.05, Mann-Whitney U-test) and the addition of 28 muM fullerene significantly suppressed the UVB-induced PGE2 production by 18.3% (p < 0.05). Conclusions: Fullerene lotion significantly decreases conspicuous facial pores after an 8-week treatment possibly through the suppression of PGE2 production in the epidermis.

Shigeki Inui

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The Journal of Physical Chemistry C

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Jinjun Ren, Long Zhang and Hellmut Eckert

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The Journal of Physical Chemistry C

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Leonor de la Cueva, Koen Lauwaet, Roberto Otero, José M. Gallego, Concepción Alonso and Beatriz H. Juarez

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Chemistry of Materials

DOI: 10.1021/cm403109k

Liming Zhang, Kai Xia, Zhuoxuan Lu, Guopeng Li, Juan Chen, Yan Deng, Song Li, Feimeng Zhou and Nongyue He

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Chemistry of Materials

DOI: 10.1021/cm403822w

Nicolas Mackiewicz, Julien Nicolas, Nadège Handké, Magali Noiray, Julie Mougin, Cyril Daveu, Harivardhan Reddy Lakkireddy, Didier Bazile and Patrick Couvreur

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DOI: 10.1021/jp4121832

Andrea Michalkova Scott, Leonid Gorb, Elizabeth A. Burns, Sergey N. Yashkin, Frances C. Hill and Jerzy Leszczynski

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The Journal of Physical Chemistry C

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Jie Gao, Yiteng Zheng, George B. Fitzgerald, Jason de Joannis, Yadan Tang, Israel E. Wachs and Simon G. Podkolzin

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The Journal of Physical Chemistry C

DOI: 10.1021/jp4113365

James G. Radich, Nevin R. Peeples, Pralay K. Santra and Prashant V. Kamat

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Periodic Mesostructured Silica Films Made Simple Using UV Light

The Journal of Physical Chemistry C

DOI: 10.1021/jp410518k

Héloïse De Paz-Simon, Abraham Chemtob, Céline Croutxé-Barghorn, Séverinne Rigolet, Laure Michelin, Loïc Vidal and Bénédicte Lebeau

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Block Copolymers Self-Assembly Allows Obtaining Tunable Micro or Nanoporous Membranes or Depth Filters Based on PMMA; Fabrication Method and Nanostructures

The Journal of Physical Chemistry C

DOI: 10.1021/jp409803u

Javier Pinto, Michel Dumon, Miguel A. Rodriguez-Perez, Ricardo Garcia and Christian Dietz

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Qingxiang Song, Meng Huang, Lei Yao, Xiaolin Wang, Xiao Gu, Juan Chen, Jun Chen, Jialin Huang, Quanyin Hu, Ting Kang, Zhengxing Rong, Hong Qi, Gang Zheng, Hongzhuan Chen and Xiaoling Gao

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Nano Letters

DOI: 10.1021/nl403677k

Haiyu Fang, Zhiqiang Luo, Haoran Yang and Yue Wu

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Structural and Magnetic Evolution of Bimetallic MnAu Clusters Driven by Asymmetric Atomic Migration

Nano Letters

DOI: 10.1021/nl404412w

Xiaohui Wei, Rulong Zhou, Williams Lefebvre, Kai He, Damien Le Roy, Ralph Skomski, Xingzhong Li, Jeffrey E. Shield, Matthew J. Kramer, Shuang Chen, Xiao Cheng Zeng and David J. Sellmyer

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