Paclitaxel and etoposide co-loaded polymeric nanoparticles for the effective combination therapy against human osteosarcoma

Background: The combination of chemotherapeutic drugs with different pharmacological action has emerged as a promising therapeutic strategy in the treatment of cancers. Present study examines the antitumor potential of paclitaxel (PTX) and etoposide (ETP)-loaded PLGA nanoparticles for the treatment of osteosarcoma. Results: The resulting drug-loaded PLGA NP exhibited a nanosize dimension with uniform spherical morphology. The NP exhibited a sustained release profile for both PTX and ETP throughout the study period without any sign of initial burst release. The combinational drug-loaded PLGA NP enhanced the cytotoxic effect in MG63 and Saos-2 osteosarcoma cell lines, in comparison to either native drug alone or in cocktail combinations. Additionally, NPs showed an appreciable uptake in MG63 cells in a time-based manner. Co-delivery of anticancer drugs resulted in enhanced cell cycle arrest and cell apoptosis. The results clearly showed that combinational drugs remarkably improved the therapeutic index of chemotherapeutic drugs. The greater inhibitory effect of nanoparticle combination would be of great advantage during systemic cancer therapy. Conclusion: Taken together, our study demonstrated that PTX-ETP/PLGA NP based combination therapy holds significant potential towards the treatment of osteosarcoma.

Bing Wang

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New hope for eradication of HIV from the body: the role of polymeric nanomedicines in HIV/AIDS pharmacotherapy

Human immunodeficiency virus continued to be the greatest challenge and killer disease of the 21st century despite the advent of potent highly active antiretroviral therapy which are limited by their severe adverse effects, significant drug interactions, frequent dosing, limited bioavailability, and less access to viral reservoir sites like macrophages. Nano- medicines are becoming new hopes in avoiding these shortcomings of conventional antiretroviral drugs. The emphasis of this review is mainly the application of polymers based nanomedicines in pharmacotherapy of HIV/AIDS. Most of the studies to date on this area are in vitro and human clinical trials are totally missed. However, many interesting points are uncovered through this review like the possibility of achieving high intracellular concentration of drugs, very good antiretroviral activity, improved bioavailability, reduced toxicity and release of the drugs from nanocarriers for long time reducing the need for frequent dosing. Indeed, a lot of assignments left behind for researchers to overcome the challenges hindering the wider application of nanomedicines in treatment of HIV/AIDS.

Jimma Lenjisa

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Label-Free, All-Optical Detection, Imaging, and Tracking of a Single Protein

Nano Letters

DOI: 10.1021/nl500234t

J. Ortega Arroyo, J. Andrecka, K. M. Spillane, N. Billington, Y. Takagi, J. R. Sellers and P. Kukura

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Tuning Electronic and Magnetic Properties of Early Transition-Metal Dichalcogenides via Tensile Strain

The Journal of Physical Chemistry C

DOI: 10.1021/jp501734s

Hongyan Guo, Ning Lu, Lu Wang, Xiaojun Wu and Xiao Cheng Zeng

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Roles of Plasmonic Excitation and Protonation on Photoreactions of p-Aminobenzenethiol on Ag Nanoparticles

The Journal of Physical Chemistry C

DOI: 10.1021/jp500728s

Sai Duan, Yue-Jie Ai, Wei Hu and Yi Luo

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Correction to “Synthesis, Structure, and Luminescence Properties of K2Ba7Si16O40:Eu2+ for White Light Emitting Diodes”

The Journal of Physical Chemistry C

DOI: 10.1021/jp502302y

Wenzhen Lv, Yongchao Jia, Qi Zhao, Wei Lü, Mengmeng Jiao, Baiqi Shao and Hongpeng You

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DNA-Mediated Anomalous Optical Coupling of Heterogeneous Metallic Nanostructures

The Journal of Physical Chemistry C

DOI: 10.1021/jp501613b

Shiho Tokonami, Keisuke Nishida, Shimpei Hidaka, Yojiro Yamamoto, Hidenobu Nakao and Takuya Iida

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Aqueous-Based Chemical Route toward Ambient Preparation of Multicomponent Core–Shell Nanotubes

ACS Nano

DOI: 10.1021/nn500942k

Hui Teng Tan, Xianhong Rui, Hong Yu, Weiling Liu, Chen Xu, Zhichuan Xu, Huey Hoon Hng and Qingyu Yan

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A Route toward Digital Manipulation of Water Nanodroplets on Surfaces

ACS Nano

DOI: 10.1021/nn500873q

Meng Cheng, Duoming Wang, Zhaoru Sun, Jing Zhao, Rong Yang, Guole Wang, Wei Yang, Guibai Xie, Jing Zhang, Peng Chen, Congli He, Donghua Liu, Limei Xu, Dongxia Shi, Enge Wang and Guangyu Zhang

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Efficiency Enhancement in ZnO:Al-Based Dye-Sensitized Solar Cells Structured with Sputtered TiO2 Blocking Layers

The Journal of Physical Chemistry C

DOI: 10.1021/jp411811q

A. Alberti, G. Pellegrino, G. G. Condorelli, C. Bongiorno, S. Morita, A. La Magna and T. Miyasaka

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Primary Oxide Latent Storage and Spillover Enabling Electrocatalysts with Reversible Oxygen Electrode Properties and the Alterpolar Revertible (PEMFC versus WE) Cell

The Journal of Physical Chemistry C

DOI: 10.1021/jp412292w

Milan M. Jaksic, Gianluigi A. Botton, Georgios D. Papakonstantinou, Feihong Nan and Jelena M. Jaksic

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SOx Oxidation Kinetics on Pt(111) and Pd(111): First-Principles Computations Meet Microkinetic Modeling

The Journal of Physical Chemistry C

DOI: 10.1021/jp501538v

H. N. Sharma, V. Sharma, T. Hamzehlouyan, W. Epling, A. B. Mhadeshwar and R. Ramprasad

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Cl Species Transformation on CeO2(111) Surface and Its Effects on CVOCs Catalytic Abatement: A First-Principles Investigation

The Journal of Physical Chemistry C

DOI: 10.1021/jp411532b

Wanglai Cen, Yue Liu, Zhongbiao Wu, Jie Liu, Haiqiang Wang and Xiaole Weng

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Complex Oscillation Patterns During the Catalytic Hydrogenation of NO2 over Platinum Nanosized Crystals

The Journal of Physical Chemistry C

DOI: 10.1021/jp412506e

Cédric Barroo, Yannick De Decker, Thierry Visart de Bocarmé and Norbert Kruse

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