Effects of dendritic core–shell glycoarchitectures on primary mesenchymal stem cells and osteoblasts obtained from different human donors

The biological impact of novel nano-scaled drug delivery vehicles in highly topical therapies of bone diseases have to be investigated in vitro before starting in vivo trials. Highly desired features for these materials are a good cellular uptake, large transport capacity for drugs and a good bio-compatibility. Essentially the latter has to be addressed as first point on the agenda. We present a study on the biological interaction of maltose-modified poly(ethyleneimine) (PEI-Mal) on primary human mesenchymal stem cell, harvested from reaming debris (rdMSC) and osteoblasts obtained from four different male donors. PEI-Mal-nanoparticles with two different molecular weights of the PEI core (5000 g/mol for PEI-5k-Mal-B and 25,000 g/mol for PEI-25k-Mal-B) have been administered to both cell lines. As well dose as incubation-time dependent effects and interactions have been researched for concentrations between 1 μg/ml to 1 mg/ml and periods of 24 h up to 28 days. Studies conducted by different methods of microscopy as light microscopy, fluorescence microscopy, transmission-electron-microscopy and quantitative assays (LDH and DC-protein) indicate as well a good cellular uptake of the nanoparticles as a particle- and concentration-dependent impact on the cellular macro- and micro-structure of the rdMSC samples. In all experiments PEI-5k-Mal-B exhibits a superior biocompatibility compared to PEI-25k-Mal-B. At higher concentrations PEI-25k-Mal-B is toxic and induces a directly observable mitochondrial damage. The alkaline phosphatase assay (ALP), has been conducted to check on the possible influence of nanoparticles on the differentiation capabilities of rdMSC to osteoblasts. In addition the production of mineralized matrix has been shown by von-Kossa stained samples. No influence of the nanoparticles on the ALP per cell has been detected. Additionally, for all experiments, results are strongly influenced by a large donor-to-donor variability of the four different rdMSC samples. To summarize, while featuring a good cellular uptake, PEI-5k-Mal-B induces only minimal adverse effects and features clearly superior biocompatibility compared to the larger PEI-25k-Mal-B.
Stefan Lautenschläger
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Highly Efficient Copper–Indium–Selenide Quantum Dot Solar Cells: Suppression of Carrier Recombination by Controlled ZnS Overlayers

ACS Nano

DOI: 10.1021/acsnano.5b04917

Jae-Yup Kim, Jiwoong Yang, Jung Ho Yu, Woonhyuk Baek, Chul-Ho Lee, Hae Jung Son, Taeghwan Hyeon and Min Jae Ko
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Predictable Shrinkage during the Precise Design of Porous Materials and Nanomaterials

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b02435

Saikat Dutta, Kevin C.-W. Wu and Tatsuo Kimura
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H2-Dependent Carbon Dissolution and Diffusion-Out in Graphene Chemical Vapor Deposition Growth

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b07127

Baoshan Hu, Yan Jin, Dongjie Guan, Zhengtang Luo, Bo Shang, Qianrui Fang and Haibo Ruan
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One-to-One Correlation between Structure and Optical Response in a Heterogeneous Distribution of Plasmonic Constructs

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b09292

Aiqin Fang, Sarah L. White, Rafael A. Masitas, Francis P. Zamborini and Prashant K. Jain
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Enhancement of Proton Ordering in the Hexagonal Ice in Contact with Polyethylene Glycol Crystal

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b05785

Atsushi Nagoe, Hiroshi Kusukawa and Masaharu Oguni
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Unraveling the Origin of Structural Disorder in High Temperature Transition Al2O3: Structure of θ-Al2O3

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b02523

Libor Kovarik, Mark Bowden, Dachuan Shi, Nancy M. Washton, Amity Andersen, Jian Zhi Hu, Jaekyoung Lee, János Szanyi, Ja-Hun Kwak and Charles H. F. Peden
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Tetrahedral Silsesquioxane Framework: A Feasible Candidate for Hydrogen Storage

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b06514

Amol Deshmukh, Yun-Wen Chen and Jer-Lai Kuo
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Photoinduced Br Desorption from CsBr Thin Films Grown on Cu(100)

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b08275

M. T. E. Halliday, A. G. Joly, W. P. Hess and A. L. Shluger
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Delicate Distinction between OH Groups on Proton-Exchanged H-Chabazite and H-SAPO-34 Molecular Sieves

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b09247

Istvan Halasz, Bjorn Moden, Anton Petushkov, Jian-Jie Liang and Mukesh Agarwal
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Metal–Dielectric Waveguides for High Efficiency Fluorescence Imaging

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b08582

Liangfu Zhu, Douguo Zhang, Ruxue Wang, Pei Wang, Hai Ming, Ramachandram Badugu, Luping Du, Xiaocong Yuan and Joseph R. Lakowicz
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UV Light Detection from CdS Nanocrystal Sensitized Graphene Photodetectors at kHz Frequencies

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b07895

Davide Spirito, Stefan Kudera, Vaidotas Miseikis, Carlo Giansante, Camilla Coletti and Roman Krahne
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Improved Up-Conversion Luminescence from Er3+:LaF3 Nanocrystals Embedded in Oxyfluoride Glass Ceramics via Simultaneous Triwavelength Excitation

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b08103

Zhi Chen, Guobo Wu, Hong Jia, Kaniyarakkal Sharafudeen, Wubin Dai, Xiaowen Zhang, Shengfeng Zeng, Jianmin Liu, Rongfei Wei, Shichao Lv, Guoping Dong and Jianrong Qiu
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Degradation by Exposure of Coevaporated CH3NH3PbI3 Thin Films

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b07676

Youzhen Li, Xuemei Xu, Chenggong Wang, Congcong Wang, Fangyan Xie, Junliang Yang and Yongli Gao
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Thermal Stability of Core–Shell Nanoparticles: A Combined in Situ Study by XPS and TEM

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b01862

Cecile S. Bonifacio, Sophie Carenco, Cheng Hao Wu, Stephen D. House, Hendrik Bluhm and Judith C. Yang
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Label-Free Nanoplasmonic-Based Short Noncoding RNA Sensing at Attomolar Concentrations Allows for Quantitative and Highly Specific Assay of MicroRNA-10b in Biological Fluids and Circulating Exosomes

ACS Nano

DOI: 10.1021/acsnano.5b04527

Gayatri K. Joshi, Samantha Deitz-McElyea, Thakshila Liyanage, Katie Lawrence, Sonali Mali, Rajesh Sardar and Murray Korc
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Bioinspired Hierarchical Surface Structures with Tunable Wettability for Regulating Bacteria Adhesion

ACS Nano

DOI: 10.1021/acsnano.5b04231

Xiao-Qiu Dou, Di Zhang, Chuanliang Feng and Lei Jiang
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Atomic Layer Deposition of Lithium Phosphorus Oxynitride

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b02199

Mikko Nisula, Yohei Shindo, Hideyuki Koga and Maarit Karppinen
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