Christopher J. DeSantis, Da Huang, Hui Zhang, Nathaniel J. Hogan, Hangqi Zhao, Yifei Zhang, Alejandro Manjavacas, Yue Zhang, Wei-Shun Chang, Peter Nordlander, Stephan Link and Naomi J. Halas Click for full article
Zhenyu Yang, Alyf Janmohamed, Xinzheng Lan, F. Pelayo García de Arquer, Oleksandr Voznyy, Emre Yassitepe, Gi-Hwan Kim, Zhijun Ning, Xiwen Gong, Riccardo Comin and Edward H. Sargent Click for full article
Xuan Zhou, Jérémie Wenger, Francesco N. Viscomi, Loïc Le Cunff, Jérémie Béal, Serguei Kochtcheev, Xuyong Yang, Gary P. Wiederrecht, Gérard Colas des Francs, Anu Singh Bisht, Safi Jradi, Roberto Caputo, Hilmi Volkan Demir, Richard D. Schaller, Jérôme Plain, Alexandre Vial, Xiao Wei Sun and Renaud Bachelot Click for full article
Miguel Cuerva, Rebeca García-Fandiño, Carlos Vázquez-Vázquez, M. Arturo López-Quintela, Javier Montenegro and Juan R. Granja Click for full article
Background: Biocompatible gold nanoparticles (GNPs) are potentially practical and efficient agents in cancer radiotherapy applications. In this study, we demonstrated that GNPs can significantly modulate irradiation response of hepatocellular carcinoma cells in vitro and investigated the underlying mechanisms. We co-grafted galactose (GAL) targeting hepatocyte specific asialoglycoprotein receptor and Polyethylene Glycol (PEG) onto GNPs surfaces to increase GNPs targeting specificity and stability. Results: This novel GAL-PEG-GNPs and bare GNPs show similar appearance and cytotoxicity profiles, while more GAL-PEG-GNPs can be effectively uptaken and could enhance cancer cell killing. Conclusion: GAL-PEG-GNPs have better radiosensitization to HepG2. The sensitization mechanism of GAL-PEG-GNPs is related to the apoptotic gene process activated by generation of a large amount of free radicals induced by GNPs.
Chuan-dong Zhu Click for full article