Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)

Background: The blood brain barrier (BBB) controls the brain microenvironment and limits penetration of the central nervous system (CNS) by chemicals, thus creating an obstacle to many medical imaging and treatment procedures. Research efforts to identify viable routes of BBB penetration have focused on structures such as micelles, polymeric nanoparticles and liposomes as drug carriers, however, many of them failed to provide unequivocal proof of BBB penetration. Here we proved that gold nanoparticles (AuNPs) penetrate the BBB in rats to reach brain regions. Results: Injection of AuNPs to the abdominal cavity of rats resulted in levels of gold found in blood, urine, brain regions and body organs. After perfusion the concentration of gold in brain regions diminished dramatically indicating that most of the gold was in venous blood and not in the brain tissues. Injection of Na, K or Ca ion channel blockers reduced BBB penetration by half. A biological half-life of 12.9 ± 4.9 h was found for the gold nanoparticles. Possible mechanisms for the transport of AuNPs through the BBB are discussed. Conclusions: BBB penetration by AuNPs is spontaneous without the application of an external field. A major amount of gold resides in blood vessels therefore perfusion required. Ion channel blockers can be used to control the transport of AuNPs.
Hagit Sela
Click for full article

Pressure-Induced Amorphization and a New High Density Amorphous Metallic Phase in Matrix-Free Ge Nanoparticles

Nano Letters

DOI: 10.1021/acs.nanolett.5b02627

Niccolo R. C. Corsini, Yuanpeng Zhang, William R. Little, Ali Karatutlu, Osman Ersoy, Peter D. Haynes, Carla Molteni, Nicholas D. M. Hine, Ignacio Hernandez, Jesus Gonzalez, Fernando Rodriguez, Vadim V. Brazhkin and Andrei Sapelkin
Click for full article

Graphene-Based Thermopile for Thermal Imaging Applications

Nano Letters

DOI: 10.1021/acs.nanolett.5b01755

Allen L. Hsu, Patrick K. Herring, Nathaniel M. Gabor, Sungjae Ha, Yong Cheol Shin, Yi Song, Matthew Chin, Madan Dubey, Anantha P. Chandrakasan, Jing Kong, Pablo Jarillo-Herrero and Tomás Palacios
Click for full article

Interfacial Control of Magnetic Properties at LaMnO3/LaNiO3 Interfaces

Nano Letters

DOI: 10.1021/acs.nanolett.5b02720

M. Gibert, M. Viret, A. Torres-Pardo, C. Piamonteze, P. Zubko, N. Jaouen, J.-M. Tonnerre, A. Mougin, J. Fowlie, S. Catalano, A. Gloter, O. Stéphan and J.-M. Triscone
Click for full article

Three-Dimensional Superlocalization Imaging of Gliding Mycoplasma mobile by Extraordinary Light Transmission through Arrayed Nanoholes

ACS Nano

DOI: 10.1021/acsnano.5b03934

Wonju Lee, Yoshiaki Kinosita, Youngjin Oh, Nagisa Mikami, Heejin Yang, Makoto Miyata, Takayuki Nishizaka and Donghyun Kim
Click for full article

Bridging the Nanogap with Light: Continuous Tuning of Plasmon Coupling between Gold Nanoparticles

ACS Nano

DOI: 10.1021/acsnano.5b05568

Heesun Jung, Hoon Cha, Daedu Lee and Sangwoon Yoon
Click for full article

Lateral and Vertical Two-Dimensional Layered Topological Insulator Heterostructures

ACS Nano

DOI: 10.1021/acsnano.5b04068

Yanbin Li, Jinsong Zhang, Guangyuan Zheng, Yongming Sun, Seung Sae Hong, Feng Xiong, Shuang Wang, Hye Ryoung Lee and Yi Cui
Click for full article

Model Driven Optimization of Magnetic Anisotropy of Exchange-Coupled Core–Shell Ferrite Nanoparticles for Maximal Hysteretic Loss

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b03261

Qian Zhang, Idoia Castellanos-Rubio, Rahul Munshi, Iñaki Orue, Beatriz Pelaz, Katharina Ines Gries, Wolfgang J. Parak, Pablo del Pino and Arnd Pralle
Click for full article

Bright Type II Quantum Dots

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b02040

Christina M. Tyrakowski, Armen Shamirian, Clare E. Rowland, Hongyan Shen, Adita Das, Richard D. Schaller and Preston T. Snee
Click for full article

Polydopamine Coatings in Confined Nanopore Space: Toward Improved Retention and Release of Hydrophilic Cargo

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b08558

Xianying Zheng, Jixi Zhang, Jie Wang, Xueqiang Qi, Jessica M. Rosenholm and Kaiyong Cai
Click for full article

Structural and Electronic Features of β-Ni(OH)2 and β-NiOOH from First Principles

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b08481

Alexander J. Tkalych, Kuang Yu and Emily A. Carter
Click for full article

Dynamical Origin of Ionic Conductivity for Li7P3S11 Metastable Crystal As Studied by 6/7Li and 31P Solid-State NMR

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b06308

Miwa Murakami, Keiji Shimoda, Shinya Shiotani, Akio Mitsui, Koji Ohara, Yohei Onodera, Hajime Arai, Yoshiharu Uchimoto and Zempachi Ogumi
Click for full article

Bioinspired Smart Gate-Location-Controllable Single Nanochannels: Experiment and Theoretical Simulation

ACS Nano

DOI: 10.1021/acsnano.5b05542

Huacheng Zhang, Ye Tian, Jue Hou, Xu Hou, Guanglei Hou, Ranwen Ou, Huanting Wang and Lei Jiang
Click for full article

Extraordinarily High Conductivity of Stretchable Fibers of Polyurethane and Silver Nanoflowers

ACS Nano

DOI: 10.1021/acsnano.5b03864

Rujun Ma, Byeongguk Kang, Suik Cho, Minjun Choi and Seunghyun Baik
Click for full article

Remarkable Conversion Between n- and p-Type Reduced Graphene Oxide on Varying the Thermal Annealing Temperature

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b02999

Nguyen Dien Kha Tu, Jaeyoo Choi, Chong Rae Park and Heesuk Kim
Click for full article

Understanding the Reaction Chemistry of 2,2′:5′,2″-Terthiophene Films with Vapor-Deposited Ag, Al, and Ca

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b08127

Lingzi Sang, Dallas L. Matz and Jeanne E. Pemberton
Click for full article

Vacancies in Si Can Improve the Concentration-Dependent Lithiation Rate: Molecular Dynamics Studies of Lithiation Dynamics of Si Electrodes

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b06953

Kwang Jin Kim and Yue Qi
Click for full article

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

Nano Letters

DOI: 10.1021/acs.nanolett.5b02497

Kevin J. Kauffman, J. Robert Dorkin, Jung H. Yang, Michael W. Heartlein, Frank DeRosa, Faryal F. Mir, Owen S. Fenton and Daniel G. Anderson
Click for full article