Hybrid Nanocluster Plasmonic Resonator for Immunological Detection of Hepatitis B Virus

Mohamed Shehata Draz, Binbin Amanda Fang, Lanjuan Li, Zhi Chen, Yingjie Wang, Yuhong Xu, Jun Yang, Kevin Killeen and Fanqing Frank Chen

ACS Nano

DOI: 10.1021/nn3034056

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Heterocoagulation as a Facile Route To Prepare Stable Serum Albumin-Nanoparticle Conjugates for Biomedical Applications: Synthetic Protocols and Mechanistic Insights

Kin Man Au and Steven P. Armes

ACS Nano

DOI: 10.1021/nn302968j

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Structure and Ionic Transport Properties of AgI1–xBrx within Single-Wall Carbon Nanotubes from Molecular Dynamics Simulation

Igor Yu. Gotlib, Alexey K. Ivanov-Schitz, Igor V. Murin, Andrey V. Petrov and Ruslan M. Zakalyukin

The Journal of Physical Chemistry C

DOI: 10.1021/jp305518t

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Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

Jamboor Vishwanatha



Background: Nanoparticle based delivery of anticancer drugs have been widely investigated. However, a very important process for Research & Development in any pharmaceutical industry is scaling nanoparticle formulation techniques so as to produce large batches for preclinical and clinical trials. This process is not only critical but also difficult as it involves various formulation parameters to be modulated all in the same process. Methods: In our present study, we formulated curcumin loaded poly (lactic acid-co-glycolic acid) nanoparticles (PLGA-CURC). This improved the bioavailability of curcumin, a potent natural anticancer drug, making it suitable for cancer therapy. Post formulation, we optimized our process by Reponse Surface Methodology (RSM) using Central Composite Design (CCD) and scaled up the formulation process in four stages with final scale-up process yielding 5 g of curcumin loaded nanoparticles within the laboratory setup. The nanoparticles formed after scale-up process were characterized for particle size, drug loading and encapsulation efficiency, surface morphology, in vitro release kinetics and pharmacokinetics. Stability analysis and gamma sterilization were also carried out. Results: Results revealed that that process scale-up is being mastered for elaboration to 5 g level. The mean nanoparticle size of the scaled up batch was found to be 158.5 [PLUS-MINUS SIGN] 9.8 nm and the drug loading was determined to be 10.32 [PLUS-MINUS SIGN] 1.4 %. The in vitro release study illustrated a slow sustained release corresponding to 75 % drug over a period of 10 days. The pharmacokinetic profile of PLGA-CURC in rats following i.v. administration showed two compartmental model with the area under the curve (AUC0-[INFINITY]) being 6.139 mg/L h. Gamma sterilization showed no significant change in the particle size or drug loading of the nanoparticles. Stability analysis revealed long term physiochemical stability of the PLGA-CURC formulation. Conclusions: A successful effort towards formulating, optimizing and scaling up PLGA-CURC by using Solid-Oil/Water emulsion technique was demonstrated. The process used CCD-RSM for optimization and further scaled up to produce 5 g of PLGA-CURC with almost similar physicochemical characteristics as that of the primary formulated batch.



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Highly Sensitive Electrochemiluminescent Nanobiosensor for the Detection of Palytoxin

Valeria Anna Zamolo, Giovanni Valenti, Enrica Venturelli, Olivier Chaloin, Massimo Marcaccio, Sabrina Boscolo, Valentina Castagnola, Silvio Sosa, Federico Berti, Giampaolo Fontanive, Mark Poli, Aurelia Tubaro, Alberto Bianco, Francesco Paolucci and Maurizio Prato

ACS Nano

DOI: 10.1021/nn302573c

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Computational Prediction of New Hydrocarbon Materials: The Hydrogenated Forms of Graphdiyne

George M. Psofogiannakis and George E. Froudakis

The Journal of Physical Chemistry C

DOI: 10.1021/jp306704b

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Methylation of Ethene by Surface Methoxides: A Periodic PBE+D Study across Zeolites

M. N. Mazar, S. Al-Hashimi, A. Bhan and M. Cococcioni

The Journal of Physical Chemistry C

DOI: 10.1021/jp306003e

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Observation of Substrate Orientation-Dependent Oxygen Defect Filling in Thin WO3−δ/TiO2 Pulsed Laser-Deposited Films with in Situ XPS at High Oxygen Pressure and Temperature

Artur Braun, Funda Aksoy Akgul, Qianli Chen, Selma Erat, Tzu-Wen Huang, Naila Jabeen, Zhi Liu, Bongjin S. Mun, Samuel S. Mao and Xiaojun Zhang

Chemistry of Materials

DOI: 10.1021/cm301829y

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A Plasmonic Fano Switch

Wei-Shun Chang, J. Britt Lassiter, Pattanawit Swanglap, Heidar Sobhani, Saumyakanti Khatua, Peter Nordlander, Naomi J. Halas and Stephan Link

Nano Letters

DOI: 10.1021/nl302610v

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Exciton Dynamics at CuPc/C60 Interfaces: Energy Dependence of Exciton Dissociation

G. J. Dutton and S. W. Robey

The Journal of Physical Chemistry C

DOI: 10.1021/jp305637r

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An Electrically-Driven GaAs Nanowire Surface Plasmon Source

Pengyu Fan, Carlo Colombo, Kevin C. Y. Huang, Peter Krogstrup, Jesper Nygård, Anna Fontcuberta i Morral and Mark L. Brongersma

Nano Letters

DOI: 10.1021/nl302521v

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Gate-Defined Confinement in Bilayer Graphene-Hexagonal Boron Nitride Hybrid Devices

Augustinus (Stijn) M. Goossens, Stefanie C. M. Driessen, Tim A. Baart, Kenji Watanabe, Takashi Taniguchi and Lieven M. K. Vandersypen

Nano Letters

DOI: 10.1021/nl301986q

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Periodic DFT Study of the Tetragonal ZrO2 Nanocrystals: Equilibrium Morphology Modeling and Atomistic Surface Hydration Thermodynamics

Witold Piskorz, Joanna Gryboś, Filip Zasada, Piotr Zapała, Sylvain Cristol, Jean-François Paul and Zbigniew Sojka

The Journal of Physical Chemistry C

DOI: 10.1021/jp3050059

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Heteroatomic Effects on Charge-Transfer Mobility of Dianthra[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DATT) and Its Derivatives

Ming-Xing Zhang and Guang-Jiu Zhao

The Journal of Physical Chemistry C

DOI: 10.1021/jp306311v

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Square Arrays of Holes and Dots Patterned from a Linear ABC Triblock Terpolymer

Hong Kyoon Choi, Jessica Gwyther, Ian Manners and Caroline A. Ross

ACS Nano

DOI: 10.1021/nn303085k

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Monodisperse Fluorescent Organic/Inorganic Composite Nanoparticles: Tuning Full Color Spectrum

Zaicheng Sun, Feng Bai, Huimeng Wu, Daniel M. Boye and Hongyou Fan

Chemistry of Materials

DOI: 10.1021/cm3016287

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Instability of Lithium Garnets against Moisture. Structural Characterization and Dynamics of Li7-xHxLa3Sn2O12 and Li5-xHxLa3Nb2O12

Cyrille Galven, Jens Dittmer, Emmanuelle Suard, Françoise Le Berre and Marie-Pierre Crosnier-Lopez

Chemistry of Materials

DOI: 10.1021/cm300964k

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Demonstration of Defect-Free and Composition Tunable GaxIn1–xSb Nanowires

Sepideh Gorji Ghalamestani, Martin Ek, Bahram Ganjipour, Claes Thelander, Jonas Johansson, Philippe Caroff and Kimberly A. Dick

Nano Letters

DOI: 10.1021/nl302497r

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