Y H Leung, C M N Chan, A M C Ng, H T Chan, M W L Chiang, A B Djurišić, Y H Ng, W Y Jim, M Y Guo, F C C Leung, W K Chan and D T W Au
In various practical applications, nanomaterials typically have functionalized surfaces. Yet, the studies of toxicity and antibacterial activity of functionalized nanoparticles are scarce. We investigated the effect of surface modifications on antibacterial activity of ZnO under ambient illumination, and we found that nanoparticles coated with different surface modifying reagents could exhibit higher or lower toxicity compared to bare ZnO, depending on the surface modifying reagent used. Different surface modifying reagent molecules resulted in differences in the release of Zn 2+ ions and the production of reactive oxygen species (ROS). However, the antibacterial activity did not correlate with the ROS levels or the Zn 2+ ion release. One of the surface-modified ZnO samples exhibited significantly lower Zn 2+ ion release while at the same time exhibiting improved antibacterial activity. In all cases, damage of the cell wall membranes and/or changes ...
Link to full article
In various practical applications, nanomaterials typically have functionalized surfaces. Yet, the studies of toxicity and antibacterial activity of functionalized nanoparticles are scarce. We investigated the effect of surface modifications on antibacterial activity of ZnO under ambient illumination, and we found that nanoparticles coated with different surface modifying reagents could exhibit higher or lower toxicity compared to bare ZnO, depending on the surface modifying reagent used. Different surface modifying reagent molecules resulted in differences in the release of Zn 2+ ions and the production of reactive oxygen species (ROS). However, the antibacterial activity did not correlate with the ROS levels or the Zn 2+ ion release. One of the surface-modified ZnO samples exhibited significantly lower Zn 2+ ion release while at the same time exhibiting improved antibacterial activity. In all cases, damage of the cell wall membranes and/or changes ...
Link to full article
No comments:
Post a Comment