Friday, July 25, 2014

Transport across the cell-membrane dictates nanoparticle fate and toxicity: a new paradigm in nanotoxicology




Nanoscale , 2014, Advance Article

DOI: 10.1039/C4NR02008A, Paper

Daniela Guarnieri, Stefania Sabella, Ornella Muscetti, Valentina Belli, Maria Ada Malvindi, Sabato Fusco, Elisa De Luca, Pier Paolo Pompa, Paolo A. Netti

Metal-containing nanoparticles are delivered to cells by a gene gun and "classical" endocytosis, finding that cytotoxicity is internalization mechanism dependent, being mainly caused by lysosomal degradation of nanoparticles.

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