Wednesday, January 28, 2015

Mechanistic insights into EGFR membrane clustering revealed by super-resolution imaging




Nanoscale , 2015, 7,2511-2519

DOI: 10.1039/C4NR04962D, Paper

Jing Gao, Ye Wang, Mingjun Cai, Yangang Pan, Haijiao Xu, Junguang Jiang, Hongbin Ji, Hongda Wang

We investigate the distribution of membrane EGFR by direct stochastic optical reconstruction microscopy (dSTORM). Our results illustrate the clustering distribution pattern of EGFR in polarized cells and uncover the essential role of lipid rafts in EGFR cluster maintenance.

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