Strong Interactions with Polyethylenimine-Coated Human Serum Albumin Nanoparticles (PEI-HSA NPs) Alter [small alpha]- Synuclein Conformation and Aggregation Kinetics

Nanoscale, 2015, Accepted Manuscript
DOI: 10.1039/C5NR05663B, Paper

Hossein Mohammad-Beigi, seyed Abbas shojaosadati, Amir Tayaranian Marvian, Jannik Nedergaard Pedersen, Lasse Hyldgaard Klausen, Gunna Christiansen, Jan S Pedersen, Mingdong Dong, Dina Morshedi, Daniel Otzen
The interaction between nanoparticles (NPs) and the small intrinsically disordered protein [small alpha]-synuclein ([small alpha]SN), whose aggregation is central in the development of Parkinson's Disease, is of great relevance in biomedical applications...
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