Erratum to: Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

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Guilan Quan
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Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography

Background: Pancreatic cancer often goes undiagnosed until late stage disease due in part to suboptimal early detection. Our goal was to develop a Syndecan-1 tagged liposome containing fluorescent dye as an improved contrast agent for detection of pancreatic adenocarcinoma in vivo using multispectral optoacoustic tomography. Results: The diagnostic capabilities and specificity to pancreatic adenocarcinoma of Syndecan-1 targeted liposomes were evaluated both in vitro and in vivo. Immunocytochemistry showed that liposomes preferentially bound to and released their contents into cells expressing high levels of insulin-like growth factor 1 receptor. We determined that the contents of the liposome were released into the cell as noted by the change in propidium iodide fluorescence from green to red based upon nucleic acid binding. In an orthotopic mouse model, the liposomes preferentially targeted the pancreatic tumor with little off-target binding in the liver and spleen. Peak accumulation of the liposomes in the tumor occurred at 8 h post-injection. Multispectral optoacoustic tomographic imaging was able to provide high-resolution 3D images of the tumor and liposome location. Ex vivo analysis showed that non-targeted liposomes accumulated in the liver, suggesting that specificity of the liposomes for pancreatic adenocarcinoma was due to the presence of the Syndecan-1 ligand. Conclusions: This study demonstrated that Syndecan-1 liposomes were able to release cargo into IGF1-R expressing tumor cells. The Syndecan-1 liposomes demonstrated tumor specificity in orthotopic pancreatic cancer as observed using multispectral optoacoustic tomography with reduced kidney and liver uptake. By targeting the liposome with Syndecan-1, this nanovehicle has potential as a targeted theranostic nanoparticle for both drug and contrast agent delivery to pancreatic tumors.
Wenyuan Yin
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Effect of the Ligand Structure on Chemical Vapor Deposition of WNxCy Thin Films from Tungsten Nitrido Complexes of the Type WN(NR2)3

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b03691

Arijit Koley, Christopher T. O’Donohue, Michelle M. Nolan, K. Randall McClain, Richard O. Bonsu, Roman Y. Korotkov, Tim Anderson and Lisa McElwee-White
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Metal Organic Frameworks Derived Hierarchical Hollow NiO/Ni/Graphene Composites for Lithium and Sodium Storage

ACS Nano

DOI: 10.1021/acsnano.5b05041

Feng Zou, Yu-Ming Chen, Kewei Liu, Zitian Yu, Wenfeng Liang, Sarang M. Bhaway, Min Gao and Yu Zhu
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Broadband Near-Infrared to Visible Upconversion in Quantum Dot–Quantum Well Heterostructures

ACS Nano

DOI: 10.1021/acsnano.5b05329

Ayelet Teitelboim and Dan Oron
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Influence of Sulfur Incorporation into Nanoporous Anodic Alumina on the Volume Expansion and Self-Ordering Degree

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b06928

I. Mínguez-Bacho, S. Rodríguez-López, A. Climent, D. Fichou, M. Vázquez and M. Hernández-Vélez
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Light-Activated Nuclear Translocation of Adeno-Associated Virus Nanoparticles Using Phytochrome B for Enhanced, Tunable, and Spatially Programmable Gene Delivery

ACS Nano

DOI: 10.1021/acsnano.5b05558

Eric J. Gomez, Karl Gerhardt, Justin Judd, Jeffrey J. Tabor and Junghae Suh
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Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules

ACS Nano

DOI: 10.1021/acsnano.5b05690

Jitendra N. Tiwari, Varun Vij, K. Christian Kemp and Kwang S. Kim
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Patterns of Flexible Nanotubes Formed by Liquid-Ordered and Liquid-Disordered Membranes

ACS Nano

DOI: 10.1021/acsnano.5b05377

Yonggang Liu, Jaime Agudo-Canalejo, Andrea Grafmüller, Rumiana Dimova and Reinhard Lipowsky
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Elongated Silicon–Carbon Bonds at Graphene Edges

ACS Nano

DOI: 10.1021/acsnano.5b06050

Qu Chen, Alex W. Robertson, Kuang He, Chuncheng Gong, Euijoon Yoon, Angus I. Kirkland, Gun-Do Lee and Jamie H. Warner
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Highly Efficient Light-Driven TiO2–Au Janus Micromotors

ACS Nano

DOI: 10.1021/acsnano.5b05940

Renfeng Dong, Qilu Zhang, Wei Gao, Allen Pei and Biye Ren
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Gold-Coated M13 Bacteriophage as a Template for Glucose Oxidase Biofuel Cells with Direct Electron Transfer

ACS Nano

DOI: 10.1021/acsnano.5b04580

Rita A. Blaik, Esther Lan, Yu Huang and Bruce Dunn
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Pressure-Induced Oriented Attachment Growth of Large-Size Crystals for Constructing 3D Ordered Superstructures

ACS Nano

DOI: 10.1021/acsnano.5b05108

Jun Wang, Gang Lian, Haibin Si, Qilong Wang, Deliang Cui and Ching-Ping Wong
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Small Molecules Based on Alkyl/Alkylthio-thieno[3,2-b]thiophene-Substituted Benzo[1,2-b:4,5-b′]dithiophene for Solution-Processed Solar Cells with High Performance

Chemistry of Materials

DOI: 10.1021/acs.chemmater.5b03889

Bin Kan, Qian Zhang, Feng Liu, Xiangjian Wan, Yunchuang Wang, Wang Ni, Xuan Yang, Mingtao Zhang, Hongtao Zhang, Thomas P. Russell and Yongsheng Chen
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Electron States of Uniaxially Strained Graphene

Nano Letters

DOI: 10.1021/acs.nanolett.5b03027

Hiroki Shioya, Saverio Russo, Michihisa Yamamoto, Monica F. Craciun and Seigo Tarucha
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Second Order Dependence on the Surface Fraction of Pt in PtRuadatom of the Oxidation of 2-PrOH in Base

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b07206

Matthew E. P. Markiewicz and Steven H. Bergens
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Co-Adsorbent Effect on the Sensitization of TiO2 and ZnO Surfaces: A Theoretical Study

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b11113

Francesca Risplendi and Giancarlo Cicero
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Assessing Interparticle J-Aggregation of Two Different Cyanine Dyes with Gold Nanoparticles and Their Spectroscopic Characteristics

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b09973

Han-Wen Cheng, Stephanie I. Lim, Weiqin Fang, Hong Yan, Zakiya Skeete, Quang Minh Ngo, Jin Luo and Chuan-Jian Zhong
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Femtosecond Electron Dynamics in Dye-Functionalized 6H-SiC(0001)

The Journal of Physical Chemistry C

DOI: 10.1021/acs.jpcc.5b09248

N. Fabian Kleimeier, Deb K. Bhowmick and Helmut Zacharias
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