Fe 3 O 4 @ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel

Low density lipoprotein (LDL)-apheresis therapy, which directly removes LDL from plasma by LDL-adsorbents in vitro is found to be clinically effective and safe to lower the LDL content in blood to prevent cardiovascular disease. Thus, developing excellent LDL adsorbents are becoming more and more attractive. Herein, functional Fe 3 O 4 @ZnO core–shell nanocomposites have been synthesized by a facile and eco-friendly two-step method. Not only do they possess high LDL adsorption (in PBS/plasma as well as on blood vessels) and favorable magnetic targeting ability but they can also be reused conveniently, which offer the Fe 3 O 4 @ZnO core–shell nanocomposites significant potential in the removal of LDL in vitro and in vivo .

Xiao Huang, Juan Lu, Danyang Yue, Yijuan Fan, Caixia Yi, Xiaoying Wang, Mengxue Zhang and Jun Pan

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