Tuesday, April 29, 2014

Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies




Nanoscale , 2014, Advance Article

DOI: 10.1039/C4NR00595C, Paper

K. Zarschler, K. Prapainop, E. Mahon, L. Rocks, M. Bramini, P. M. Kelly, H. Stephan, K. A. Dawson

Nanoparticles functionalized with single domain antibodies are shown to specifically target the EGF receptor in vitro. We investigate the effects on uptake and specificity when increasing the environmental serum toward more in vivo "realistic" concentrations.

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