Friday, November 06, 2015

Antisense precision polymer micelles require less poly(ethylenimine) for efficient gene knockdown

Nanoscale, 2015, Accepted Manuscript
DOI: 10.1039/C5NR05157F, Paper
Johans Fakhoury, Thomas G W Edwardson, Justin Conway, Tuan Trinh, Farhad Khan, Maciej Barlog, Hassan Bazzi, Hanadi Sleiman
Therapeutic nucleic acids are powerful molecules for shutting down protein expression. However, their cellular uptake is poor and requires transport vectors, such as cationic polymers. Of these, poly(ethylenimine) (PEI) has...
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