Wednesday, December 02, 2015

Highly sensitive self-complementary DNA nanoswitches triggered by polyelectrolytes

Nanoscale, 2015, Advance Article
DOI: 10.1039/C5NR05193B, Paper
Jincai Wu, Feng Yu, Zheng Zhang, Yong Chen, Jie Du, Atsushi Maruyama
A cationic comb-type copolymer (CCC) accelerates dimerization of self-complementary stem-loop DNA. Further, an anionic polymer dissociates CCC from the duplex, and then single stem-loop DNA spontaneously transforms from its dimer. Thus we can easily control the dimer and stem-loop DNA by switching on/off CCC activity.
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