Thursday, November 27, 2014

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress




Nanoscale , 2015, Advance Article

DOI: 10.1039/C4NR05509H, Paper

Hui-Wen Chiu, Tian Xia, Yu-Hsuan Lee, Chun-Wan Chen, Jui-Chen Tsai, Ying-Jan Wang

NH2 -PS induces ER stress through ROS generation and misfolded protein aggregation. Meanwhile, inhibition of the Akt/mTOR and activation of the AMPK signaling pathway was found to trigger autophagic cell death via an increase of autophagic flux or blockage of autophagosome-lysosome fusion.

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