Monday, July 01, 2013

RNase non-sensitive and endocytosis independent siRNA delivery system: delivery of siRNA into tumor cells and high efficiency induction of apoptosis




Nanoscale , 2013, Advance Article

DOI: 10.1039/C3NR01183F, Paper

Xinglu Jiang, Guobao Wang, Ru Liu, Yaling Wang, Yongkui Wang, Xiaozhong Qiu, Xueyun Gao

siRNA was successfully delivered into cytosol, escaping endosome/lysosome trapping and degradation by CPP and SWCNTs, and significantly cleaved mRNA.

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