Thursday, July 04, 2013

Cytotoxicity and DNA cleavage with core-shell nanocomposites functionalized by a KH domain DNA binding peptide




Nanoscale , 2013, Advance Article

DOI: 10.1039/C3NR02203J, Paper

Remon Bazak, Jan Ressl, Sumita Raha, Caroline Doty, William Liu, Beau Wanzer, Seddik Abdel Salam, Samy Elwany, Tatjana Paunesku, Gayle E. Woloschak

Photoexcitation DNA targeted Fe3 O4 @TiO2 nanocomposites using hnRNPK protein as a targeting moiety resulted in production of ROS close to the DNA which initiated significant DNA cleavage and apoptosis.

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