Wednesday, October 23, 2013

Antibody-drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin




Nanoscale , 2013, Advance Article

DOI: 10.1039/C3NR04268E, Paper

Elisabetta Falvo, Elisa Tremante, Rocco Fraioli, Carlo Leonetti, Carlotta Zamparelli, Alberto Boffi, Veronica Morea, Pierpaolo Ceci, Patrizio Giacomini

A novel antibody-drug conjugate (ADC) was synthesized incorporating ferritin-based nanoparticles containing cisplatin. This ADC is able to specifically deliver anticancer drugs to melanoma both in vitro and in vivo.

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