Monday, February 03, 2014

Amplified detection of femtomolar DNA based on a one-to-few recognition reaction between DNA-Au conjugate and target DNA




Nanoscale , 2014, Advance Article

DOI: 10.1039/C3NR05625B, Paper

Zhijuan Wang, Juan Zhang, Changfeng Zhu, Shixin Wu, Daniel Mandler, Robert S. Marks, Hua Zhang

A sensitive electrochemical DNA biosensor is fabricated by immobilizing a capture probe on a Au electrode, which then hybridizes with the target DNA, and further hybridizes with a DNA-Au conjugate. The detection limit of this DNA biosensor can be as low as 50 fM.

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