Cancer therapy improvement with mesoporous silica nanoparticles combining photodynamic and photothermal therapy

In this work, we develop novel mesoporous silica composite nanoparticles ( hm -SiO 2 (AlC 4 Pc)@Pd) for the co-delivery of photosensitizer (PS) tetra-substituted carboxyl aluminum phthalocyanine (AlC 4 Pc) and small Pd nanosheets as a potential dual carrier system to combine photodynamic therapy (PDT) with photothermal therapy (PTT). In the nanocomposite, PS AlC 4 Pc was covalently conjugated to a mesoporous silica network, and small Pd nanosheets were coated onto the surface of mesoporous silica by both coordination and electrostatic interaction. Since small Pd nanosheets and AlC 4 Pc display matched maximum absorptions in the 600–800 nm near-infrared (NIR) region, the fabricated hm -SiO 2 (AlC 4 Pc)@Pd nanocomposites can generate both singlet oxygen and heat upon 660 nm single continuous wavelength (CW) laser irradiation. In vitro results indicated that the cell-killing efficacy by simultaneous PDT...

Z X Zhao, Y Z Huang, S G Shi, S H Tang, D H Li and X L Chen

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