Friday, May 29, 2015

Induction of apoptosis in human cancer cells by targeting mitochondria with gold nanoparticles

Nanoscale, 2015, Advance Article
DOI: 10.1039/C5NR01483B, Paper
M. M. Mkandawire, M. Lakatos, A. Springer, A. Clemens, D. Appelhans, U. Krause-Buchholz, W. Pompe, G. Rodel, M. Mkandawire
Gold nanoparticles conjugated with mitochondria-targeting mitoTGFP and coated with 3rd generation dendrimers successfully reached the mitochondrion in a human cancer cell, while both unconjugated and uncoated AuNPs are encapsulated in endosomes and exocytosed.
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