Wednesday, September 11, 2013

Modulation of hydrogel nanoparticle intracellular trafficking by multivalent surface engineering with tumor targeting peptide




Nanoscale , 2013, Advance Article

DOI: 10.1039/C3NR00908D, Paper

Leshern Karamchand, Gwangseong Kim, Shouyan Wang, Hoe Jin Hah, Aniruddha Ray, Ruba Jiddou, Yong-Eun Koo Lee, Martin A. Philbert, Raoul Kopelman

Hydrogel nanoparticles when surface functionalized with multiple F3 peptides exhibit remarkable 'lysosome-evasive' capabilities, after internalization in tumor cells, whereas the non-functionalized nanoparticles, or F3 peptides alone, sequester within lysosomes.

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