Tuesday, June 03, 2014

A microfluidic method for synthesis of transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia

Nanoscale , 2014, Accepted Manuscript

DOI: 10.1039/C4NR01510J, Paper

Zhaogang Yang, Bo Yu, Jing Zhu, Xiaomeng Huang, Jing Xie, Songlin Xu, Xinmei Wang, Bryant C. Yung, L.James Lee, Robert Lee, Lesheng Teng

siRNA LOR-1284 targets the R2 subunit of ribonucleotide reductase (RRM2) and has shown promise in cancer therapy. In this study, transferrin (Tf) conjugated lipid nanoparticles (Tf-NP-LOR-1284) were synthesized by microfluidic...

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