Tuesday, June 24, 2014

Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications




Nanoscale , 2014, Advance Article

DOI: 10.1039/C4NR02312A, Paper

Lining Sun, Zuwu Wei, Haige Chen, Jinliang Liu, Jianjian Guo, Ming Cao, Tieqiao Wen, Liyi Shi

Three kinds of folate-targeted up-conversion nanoparticle imaging agents were prepared. These nanoparticles show good biocompatibility and up-conversion luminescence emission in water, and low cytotoxicity in vivo and in vitro. They were successfully applied to the targeted imaging of HeLa cells.

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