Hypoxia is the major hindrance to successful radiation therapy of tumors. Attempts to increase the oxygen (O 2 ) tension (PO 2 ) of tissue by delivering more O 2 have been clinically disappointing, largely due to the way O 2 is transported and released by the hemoglobin (Hb) within the red blood cells (RBCs). Systemic manipulation of O 2 transport increases vascular resistance due to metabolic autoregulation of blood flow to prevent over oxygenation. This study investigates a new technology to increase O 2 delivery to a target tissue by decreasing the Hb-O 2 affinity of the blood circulating within the targeted tissue. As the Hb-O 2 affinity decreases, the tissue PO 2 to satisfy tissue O 2 metabolic needs increases without increasing O 2 delivery or extraction. Paramagnetic nanoparticles (PMNPs), synthetized using gadolinium oxide, were coated with the cell permeable Hb all...
Click for full article
Click for full article
No comments:
Post a Comment