Multifunctional Non-viral Gene Vectors with Enhanced Stability, Improved Cellular and Nuclear Uptake Capability, and Increased Transfection Efficiency

Nanoscale , 2014, Accepted Manuscript

DOI: 10.1039/C4NR02395A, Paper

Zhe Yang, Zhaozhong Jiang, Zhong Cao, Chao Zhang, Di Gao, Xingen Luo, Xiaofang Zhang, Huiyan Luo, Qing Jiang, Jie Liu

We have developed a new multifunctional, non-viral gene delivery platform consisting of cationic poly(amine-co-ester) (PPMS) for DNA condensation, PEG shell for nanoparticle stabilization, poly([gamma]-glutamic acid) ([gamma]-PGA) and mTAT (a cell-penetrating...

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