Monday, June 02, 2014

Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain




Nanoscale , 2014, Advance Article

DOI: 10.1039/C3NR06737H, Paper

B. Newland, A. Aied, A. V. Pinoncely, Y. Zheng, T. Zhao, H. Zhang, R. Niemeier, E. Dowd, A. Pandit, W. Wang

A cationic knot structured transfection vector showed a more favorable transfection profile for a neural cell type compared to other polyplexes whilst maintaining cell viability at over 80% after four days of culture and could mediate luciferase overexpression in the adult brain.

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