Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations

Nanoscale, 2015, 7,9825-9834
DOI: 10.1039/C5NR01474C, Paper

Emil L. Kristoffersen, Line A. Jorgensen, Oskar Franch, Michael Etzerodt, Rikke Frohlich, Lotte Bjergbaek, Magnus Stougaard, Yi-Ping Ho, Birgitta R. Knudsen
Human DNA topoisomerase I (hTopI) is a nuclear enzyme that catalyzes relaxation of super helical tension that arises in the genome during essential DNA metabolic processes.
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