Nanoscale , 2013, Advance Article
DOI: 10.1039/C3NR02787B, Paper
DOI: 10.1039/C3NR02787B, Paper
P. Scodeller, P. N. Catalano, N. Salguero, H. Duran, A. Wolosiuk, G. J. A. A. Soler-Illia
Hacking the way into tumors. We report the first nanoformulation of Hyaluronidase (Hyal) self-assembled onto a polymer-modified silica surface. This enzyme-nanoparticle composite presents an enhanced adjuvant effect for the antitumoral action of carboplatin on melanoma via the degradation of the extracellular matrix (ECM). This concept could prove useful in future therapies.
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Hacking the way into tumors. We report the first nanoformulation of Hyaluronidase (Hyal) self-assembled onto a polymer-modified silica surface. This enzyme-nanoparticle composite presents an enhanced adjuvant effect for the antitumoral action of carboplatin on melanoma via the degradation of the extracellular matrix (ECM). This concept could prove useful in future therapies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
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