Thursday, August 22, 2013

Modulation of Hydrogel Nanoparticle Intracellular Trafficking by Multivalent Surface Engineering with Tumor Targeting Peptide

Nanoscale , 2013, Accepted Manuscript

DOI: 10.1039/C3NR00908D, Paper

Leshern Karamchand, Gwangseong Kim, Shouyan Wang, Hoe Jin Hah, Aniruddha Ray, Ruba Jiddou, Yong-Eun Koo Lee, Martin Philbert, Raoul Kopelman

Surface engineering of a hydrogel nanoparticle (NP) with the tumor-targeting ligand, F3 peptide, enhances both the NP's binding affinity for, and internalization by, nucleolin overexpressing tumor cells. Remarkably, the F3-functionalized...

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