Mei Lin, Dongsheng Zhang, Junxing Huang, Jia Zhang, Wei Xiao, Hong Yu, Lixin Zhang and Jun Ye
Joint therapy is a promising area of study in cancer treatment. In this paper, we prepared Mn–Zn ferrite (Mn 0.5 Zn 0.5 Fe 2 O 4 ) magnetofluid using PEI as a surfactant, and investigated the anticancer effect of Mn 0.5 Zn 0.5 Fe 2 O 4 magnetic fluid hyperthermia (MFH) combined with radiotherapy on hepatocellular carcinoma. Both in vitro and in vivo results suggest that this combined treatment with MFH and radiation has a better therapeutic effect than either of them alone. The apoptotic rate and necrotic rate of the combined treatment group was 38.80 and 25.20%, respectively. In contrast, it was only 7.49 and 3.62% in the radiation-alone group, 15.23 and 7.90% in the MFH-alone group, only 3.52 and 2.16% in the blank control group, and 23.56 and 27.56% in the adriamycin group. The cell proliferation inhibition rate of the combined treatment group (88.5%) was significantly higher than that of th...
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Joint therapy is a promising area of study in cancer treatment. In this paper, we prepared Mn–Zn ferrite (Mn 0.5 Zn 0.5 Fe 2 O 4 ) magnetofluid using PEI as a surfactant, and investigated the anticancer effect of Mn 0.5 Zn 0.5 Fe 2 O 4 magnetic fluid hyperthermia (MFH) combined with radiotherapy on hepatocellular carcinoma. Both in vitro and in vivo results suggest that this combined treatment with MFH and radiation has a better therapeutic effect than either of them alone. The apoptotic rate and necrotic rate of the combined treatment group was 38.80 and 25.20%, respectively. In contrast, it was only 7.49 and 3.62% in the radiation-alone group, 15.23 and 7.90% in the MFH-alone group, only 3.52 and 2.16% in the blank control group, and 23.56 and 27.56% in the adriamycin group. The cell proliferation inhibition rate of the combined treatment group (88.5%) was significantly higher than that of th...
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